Since I figured out how to use them I like them all. Strat quack positions 2&4 with slight adjustment of the tone knobs brings it out. There is also a Wah effect you can get using your pick and skin of your finger. With some effort it’s quite pronounced.
Les Paul type guitars the with both pickups on and the pots dimed, turn back the volume a little on the neck and then the same on the bridge. Those are the sweet tones from those guitars.
Over the years I found it’s not the big adjustments but fine adjustments and patience the can yield wonderful results.