I'd have to go with the Swiss Army Knife:
It's not my best guitar, nor my worst, but it's by far the most versatile.
HSS Floyd Rose Strat with the following mods:
Original Floyd Rose replaces the cheap Ping-licensed Floyd Rose
Seymour Duncan Pearly Gates in the humbucker slot, two Bill Lawrence noiseless L-200's in the middle & neck
Coil split switch for the humbucker
Volume wired with Treble Bleed kit
Wired for master Tone control with a No-Load Tone Pot
Blender Pot (for pseudo-Tele sounds)
Tremel-No to turn the Floyd Rose into a hard-tail.
D-Tuna added
If I didn't need versatility? My Telecaster, no question about it.