I run a MIM Fender Tele w/Seymour Duncan JB into both a boosted 6505 and a Mesa Dual, my other guitar is a les paul custom, the tele is obviously a little thinner sounding.
Been thinking about putting a slightly bassier pickup in the tele but havent gotten around to it.
FWIW i play in melodic proggy/ambient black metal band, i use a decimator with both setups and im pretty sure live the crowd a) cant tell the difference in tone and b) dont give a {censored} anyway