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TheExtractor is a PC VST plug-in that can extract audio information in real-time and convert it into MIDI messages, as well as allowing you to control up to 4 parameters at the same time from a single audio source.
With TheExtractor, it is possible to control your favorite synthesizer/sampler or effect unit (as long as they accept MIDI data) by using audio input instead of a MIDI keyboard.
TheExtractor is a VST plug-in for Windows that can be purchased online for $34.95. Demo version and audio examples are also available.