Yes have a 64 bit on my tower which I installed last week and it seemed like so much fun that I installed it here in the 32 bit format.
First off, they have changed the way things work !! No more full screen button (or I just can't find it). The default file manager uses "tabs" instead of 2 windows and I haven't figured out how to show HIDDEN files and directories. I was easily able to update to Firefox 18 (from17) but have been unable to get FLASH working for YouTube. I went to http://java.com to get the java plugin (RPM) and after downloading it, Fedora wouldn't accept the certificate ?? ...from java.com ??? I installed Audacity with no problem.
So it is another small learning curve here. I got away from Ubuntu about 6 months ago after they went to that weird 3d file folder format.
Why did I bother with a new install? My PCLinuxOS was not being supported and I was getting security warnings for the past 3 months.
The Ubuntu, in my tower, wasn't allowing updates, as well.